► Patients should be warned about drowsiness effect of prochlorperazine during the early day of treatment and advised not to drive or operate machinery.
► This drug may increase sensitivity to sunlight. Prolonged exposure to sunlight should be avoided, and a sunscreen and protective clothing should be used when body is exposed to sun.
► Patients should be advised to avoid heat exposure. Prochlorperazine may interfere the thermoregulatory mechanisms and making more susceptible to heat stroke.
► On long-term therapy of prochlorperazine, particularly during the first two to three months, periodic blood counts and liver function tests should be monitored as blood dyscrasias and cholestatic jaundice may occur. In these cases discontinuation of prochlorperazine is required.
► It should be given with great caution in patients with glaucoma or prostatic hypertrophy due to its anticholinergic action.
► Prochlorperazine may increase the pharmacological effects of barbiturates, opiates, general anesthetics, and other CNS depressant drugs. So, the doses of these drugs should be reduced if administered concomitantly.
► It potentiates the effects of anticholinergic drugs. Concomitant administration of prochlorperazine and anticholinergic drugs may cause paralytic ileus especially in the elderly persons. If constipation develops, caution should be observed.
► Hypotension and ECG changes, particularly reversible Q wave and T wave distortions may be seen after administration of prochlorperazine. So, prochlorperazine should be used with caution in patients with cardiovascular disease.
► Children with acute febrile illness or suffering from dehydration are more susceptible than adults to develop dystonias. So, prochlorperazine should be given under close supervision and at low doses in such children.
► The incidence of adverse effects of prochlorperazine is greater in persons over 55 years of age. So, the maintenance dosage of prochlorperazine should be reduced to lowest effective level to minimize this possibility.
► High doses of prochlorperazine should be avoided in known seizure patients because it may predispose seizures.
► It may potentiate the effects of alcohol and producing extreme drowsiness.